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Animal free murine 3D-M®Repro

ReproTox has developed an animal-free 3D testicular cell co-culture system (3D-T®Repro) from a combination of testicular cell lines. This model has gone through extensive biomarker and morphology testing to ensure that it reflects In vitro condition and provides affordable, humane, and efficient methods for reproductive and developmental toxicity screening.


ReproTox has developed a proprietary technology to establish in vitro 3D testicular model at different stage of spermatogenesis from mice, rats and canine. We derived testicular cells from neonate, juvenile and adolescent, established these testicular-like organiod representing differential stages of spermatogensis. This organiod culture recapitulate many features of spermatogenesis in vivo, and enable assessment of differentiation and mitosis. This technology provides a reliable, robust, and relevant in vitro system for preclinical drug discovery, repro-toxicity assessment, and disease modeling.An extensive panel of toxicological endpoints is assessed in multiple cell types and at multiple time points using High-Content screening (HCS). By combining these endpoints withexposure levels, the system delivers a sensitive and specific prediction of repro-toxicity.


3D-T®Repro_EX-Vivo provides an innovative technology to culture seminiferous tubes, enable the spermatogenesis In vitro. The technology preserves the original structure of the seminiferous tubules, and the Sertoli cells remain polarized which is crucial for the differentiation of germ cells. Thus, it allows the study of both spermatogenesis in mitotic and meiotic phases.

High-Content BioAssay System

ReproTox is at the forefront of cell-based High- Throughput (HT) and pathway-based High- Content Analysis (HCA) for reproductive-toxicity evaluations. This means we can provide a fully automated high-throughput screen and high- content analysis as well as access to the reproductive toxicity database developed by ReproTox (150 compounds). ReproTox has developed a variety of fluorescent based High- Content Assays with a microplate format, enabling a rapid and quantitative readout suitable for High- Content Analysis.
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Examples of In Vitro Assays

Assay No Name/Species Endpoint Cell Type Price
CS-SCs Canine Sertoli Cell Viability/Cytotoxicity, Multiplexed High-Content analysis Canine, Primary Sertoli Cell Quote
MU-SCs Mouse Sertoli Cell Viability/Cytotoxicity, Multiplexed High-Content analysis Mouse, Sertoli Cell Line Quote
MU-LCs Mouse Leydig Cell Viability/Cytotoxicity, Multiplexed High-Content analysis Mouse, Leydig Cell Line Quote
MU-SPs Mouse Spermotogonial Cell Viability/Cytotoxicity, Multiplexed High-Content analysis Mouse, Spermotogonial Cell Quote
HU-SCs Human Sertoli Cell Viability/Cytotoxicity, Multiplexed High-Content analysis Huamn Primary Sertoli Cells Quote
HU-LCs Human Leydig Cell Viability/Cytotoxicity, Multiplexed High-Content analysis Human primary Leydig Cells Quote
3D-T®Repro_Primary Canine Canine Organoid Viability/Cytotoxicity, Multiplexed High-Content analysis Canine Primary Sertoli Cell Quote
3D-T®Repro_Primary Mouse Mouse reproductive 3D model Viability/Cytotoxicity, Multiplexed High-Content analysis Mouse primary testicular cells Quote
3D-T®Repro_Primary Rat Rat reproductive primary cell 3D model Multiplexed High-Content analysis Rat primary testicular cells Quote