March 2023

High-content analysis of testicular toxicity of BPA and its selected analogs in mouse spermatogonial, Sertoli cells, and Leydig cells revealed BPAF induced unique multinucleation phenotype associated with the increased DNA synthesis
 Lei Yin, Chelin Hu, Xiaozhong (John) Yu , Toxicology in Vitro,  Available online 21 March 2023, 105589

Photoaging of polystyrene microspheres causes oxidative alterations to surface physicochemistry and enhances airway epithelial toxicity
 Eliane El Hayek, Eliseo Castillo, Julie G In, Marcus Garcia, Jose Cerrato, Adrian Brearley, Jorge Gonzalez-Estrella, Guy Herbert, Barry Bleske, Angelica Benavidez, Hsuan Hsiao, Lei Yin, Matthew J Campen, Xiaozhong Yu  Toxicological Sciences  DOI: 10.1093/toxsci/kfad023

The role of small GTPases in bisphenol AF -induced multinucleation in comparison with dibutyl phthalate in the male germ cells.
Hu C, Hsiao ZH, Yin L, Yu X. Toxicol Sci. 2023 Jan 10

Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells.
Li Y, Li X, Cournoyer P, Choudhuri S, Yu X, Guo L, Chen S.  Toxicol Sci. 2023 Feb 17;191(2):227-238.

August 2022

Exposure to zinc oxide nanoparticles affects testicular structure, reproductive development and spermatogenesis in parental and offspring male rats.
Hong X, Shao N, Yin L, Li C, Tao G, Sun Y, Qian K, Yang J, Xiao P, Yu X, Zhou Z.Ann
Transl Med. 2022 Jul;10(13):751.

July 2022

Characterization of primary canine Sertoli cells as a model to test male reproductive toxicant.(PDF)

Zoey Hsuan Hsiao, Lu Li, Xiaozhong (John) Yu, Lei Yin*
Toxicology in Vitro  2022 Jul. 31st

March 2022

SOT 2022 Poster Presentations

ReproTOX biotech presented its latest research at the 61st Annual Society of Toxicology Meeting (SOT) in San Diego, March 27-31, 2022. The company's principal scientists  discussed and shared our newest discoveries with other scientists.

4190: Poster Board - P120: Development of Canine Testicular Organoids for Assessing Male Reproductive Toxicity. 

(Board no. P120 9:00 am - 10:45 am Wed, Mar 30 Pacific time).

4187: Poster Board - P117: Establishment, Characterization, and Toxicological Application of Canine Primary Sertoli Cells. 

(Board no. P117 9:00 am - 10: 45 Wed, Mar 30  Pacific time).

4195: Poster Board - P125: High Content Imaging Analysis for the Testicular Toxicity Prediction Using an 87-Compound Library in a Three Dimensional Testicular Cell Co-culture Model.  (Board no. P125 9:00 am - 10:45 am Wed, Mar 30  Pacific time).

February 2020

High- Content Image-Based Single-Cell Phenotypic Analysis for the Testicular Toxicity Prediction Induced by Bisphenol A and Its Analogs Bisphenol S, Bisphenol AF, and Tetrabromobisphenol A in a Three-Dimensional Testicular Cell Co-culture Model. (PDF)

Lei Yin, Jacob Steven Siracusa, Emily Measel, Xueling Guan, Clayton Edenfield, Shenxuan Liang, Xiaozhong Yu
Toxicol Sci. 2020 Feb 1; 173(2): 313-335. https://doi: 10.1093/toxsci/kfz233.

September 2019

NaCl Nanoparticles as a Cancer Therapeutic. (PDF)

Wen Jiang, Lei Yin, Hongmin Chen, Amy Victoria Paschall, Liuyang Zhang, Wenyan Fu, Weizhong Zhang, Trever Todd, Kevin Shengyang Yu, Shiyi Zhou, Zipeng Zhen, Michael Butler, Li Yao, Feng Zhang, Ye Shen, Zibo Li, Amelia Yin, Hang Yin, Xianqiao Wang, Fikri Y Avci, Xiaozhong Yu, Jin Xie.
Adv Mater. 2019 Nov; 31(46): e1904058. https://doi: 10.1002/adma.201904058. Epub 2019 Sep 25.

October 2018

Manipulation of Single Cells Using a Ferromagnetic Nanorod Cluster Actuated by Weak AC Magnetic Fields.

Lu Zhu, Weijie Huang, Fengchang Yang, Lei Yin, Shenxuan Liang, Wujun Zhao, Leidong Mao, Xiaozhong John Yu, Rui Qiao, Yiping Zhao
Adv Biosyst. 2019 Jan; 3(1): e1800246. http://doi: 10.1002/adbi.201800246. Epub 2018 Oct 17.

June 2018

Arsenic-induced apoptosis in the p53-proficient and p53-deficient cells through differential modulation of NFkB pathway.

Lei Yin, Xiaozhong Yu.
Food Chem Toxicol. 2018 Aug; 118: 849-860. https://doi: 10.1016/j.fct.2018.06.053. Epub 2018 Jun 23.

July 2017

An Animal-Free In Vitro Three-Dimensional Testicular Cell Co-culture Model for Evaluating Male Reproductive Toxicants. (PDF)

January 2017

High- Content Analysis Provides Mechanistic Insights into the Testicular Toxicity of Bisphenol A and Selected Analogues in Mouse Spermatogonial Cells.(PDF)